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Post-transcriptional Gene Regulation in Human Disease
ISBN: 9780323913058
Published: 2022
Publisher: Academic Press
Language: English
Format: Paperback / softback
Format: 9.25×7.5
Published: 2022
Publisher: Academic Press
Language: English
Format: Paperback / softback
Format: 9.25×7.5
Description
<i>Post-transcriptional Gene Regulation in Human Disease</i>, a new volume in the <i>Translational Epigenetics</i> book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail.
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