RAS: Past, Present, and Future - Humanitas

RAS: Past, Present, and Future

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ISBN: 9780128244852
Leidimo metai: 2022
Leidėjas: Academic Press
Leidinio kalba: Anglų
Formatas: Kieti viršeliai
Formatas: 9×6
Aprašymas
<i>Advances in Cancer Research, volume 153</i> provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once “undruggable” RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers.

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